My current research is focused on curriculum development and increasing the representation of minorities in STEM.
My current research is focused on curriculum development and increasing the representation of minorities in STEM.
My Ph.D. research aimed to use biomaterial approaches to understand outside-in-signaling of cells. Extracellular signals such as stiffness of the environment, presence of proteins, and tensile/contractile forces can guide cells in a variety of functions such as cell growth, migration, and stem cell differentiation. The goal was to research how these extracellular signals propagate into the nucleus and influence the epigenetic landscape in order to change gene expression.
The propagation of mechanochemical signals from the extracellular matrix to the cell nucleus has emerged as a central feature in regulating cellular differentiation and de-differentiation. I wish to explore how mechanotransduction influences the activity of chromatin modifying enzymes that direct gene expression programs, specifically histone deacetylase (HDAC) activity.